28 March 2025
Prof. Margaret Gardel
We are pleased to announce that the CPB is supporting the seminar hosting Prof. Margaret Gardel, Horace B. Horton Professor of Physics, Molecular Genetics and Cell Biology and Molecular Engineering, University of Chicago.
Mechanical Information Processing in Adherent Cells
My research group explores how shape and movements are controlled from the sub-cellular to tissue scale, with a primary focus on understanding how mechanical forces are generated, transmitted, and sensed in the actomyosin cytoskeleton to regulate cell adhesion and shape. My seminar will cover our recent efforts to understand how the actin cytoskeleton exploits mechanochemical feedbacks via LIM domain proteins to smoothly change cell mechanics and shape. I will focus on recent understanding of how transcription and mechanochemical feedbacks of the LIM protein FHL2 is harnessed for endothelial mechanobiology. I will also describe how we are incorporating data science approaches into our practice to advance quantitative biology and biophysics.
Time/Location: Friday, 28th March at 14:00, Department of Biochemistry
